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Elevated FGF21 and triglycerides in SLC25A13 carriers support the G3P-ChREBP Citrin Deficiency disease hypothesis
2025-12-12
endocrinology
Title + abstract only
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BackgroundPeople with Citrin Deficiency (CD), inactivated for both copies of SLC25A13, have lean metabolic dysfunction-associated steatotic liver disease (MASLD) and an aversion to sweets. The mouse model of CD, which inactivates Slc25a13 and Gpd2, has been shown to elevate hepatic glycerol-3-phosphate (G3P) and activate carbohydrate response element binding protein (ChREBP) thereby increasing lipogenic transcription, which could account for MASLD, and circulation of FGF21, which could account f...
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