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Brain size links neurodevelopment to neurodegeneration in Parkinson's disease
2025-12-11
neurology
Title + abstract only
View on medRxiv
Show abstract
Genetic studies have advanced our understanding of Parkinsons disease (PD) pathogenesis, establishing a role for autophagy and lysosomal dysfunction. However, how genetic risk translates into neuronal vulnerability remains mostly unknown. Using recent genome-wide association studies and neuroimaging data from UK Biobank, we show that higher polygenic risk score of PD correlates with greater cortical surface area, white matter fractional anisotropy and subcortical volumes. Mendelian randomization...
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