A Comparative Evaluation of Adjuvants for Enhancing Antibody Responses to a Nanoparticle-Based Malaria Vaccine
Nepal, Y.; Francian, A.; Roberts, B. T.; Khan, R.; Wondra, G.; Apel, F.; Demierre, A.; Chackerian, B.
Show abstract
Effective pre-erythrocytic Plasmodium falciparum vaccines targeting circumsporozoite protein (CSP) must elicit strong and durable antibody responses. We assessed the ability of different classes of adjuvants to enhance immunity of a promising CSP-epitope-targeted virus-like particle (VLP)-based vaccine. Five formulations significantly increased anti-CSP IgG titers and several also enhanced antibody durability. This study identifies promising adjuvants that enhance both the magnitude and longevity of VLP-induced immunity.
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