The influence of 2-aminoethoxydiphenyl borate on the electrical activity of the rat heart under hypoxia/reoxygenation conditions
Kharkovskaya, E.; Osipov, G. V.; Mukhina, I. V.
Show abstract
The aim of the study was to apply the multi-electrode mapping method to investigate the effect of 2-aminoethoxydiphenyl borate (2-apb) on the electrical activity and vessels of the isolated rat heart under hypoxia/reoxygenation injury (H/R). To date, the ability to influence on the calcium currents and condition of gap junctions has been shown for 2-apb. Changes in the intracellular calcium concentration in the heart play the pivotal role in the development of H/R. As a result, it was shown that 2-apb influences on the myocardial conduction velocity, sinus rhythm and coronary blood flow in the isolated rat heart. 2-apb caused heart fibrillation during normoxia but not under hypoxia, and attenuated the effect of the H/R on heart rate and vascular function.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Preventive training interferes with mRNA-encoding myosin 7 and collagen I expression during pulmonary arterial hypertension 96%
- Assessing Red Blood Cell Distribution Width in Vietnamese Heart Failure Patients: A Cross-Sectional Study 95%
- Phenylephrine induces relaxation of longitudinal strips from small arteries of goat legs 95%
Similar papers in this journal
- A compact multifunctional model of the rabbit atrioventricular node with dual pathways 92%
- Atrioventricular nodal reentrant tachycardia onset,sustainability, and spontaneous termination in rabbit atrioventricular node model with autonomic nervous system control 92%
- Machine Learning prediction of cardiac resynchronisation therapy response from combination of clinical and model-driven data 92%
Similar papers in this journal
Similar papers in this journal
Similar papers in this journal
- Transmural and rate-dependent profiling of drug-induced arrhythmogenic risks through in silico simulations of multichannel pharmacology 96%
- Dystrophin and calcium current are decreased in cardiomyocytes expressing Cre enzyme driven by αMHC but not TNT promoter 94%
- Integrating Bioinformatics and Machine Learning to Investigate the Mechanisms by Which Three Major Respiratory Infectious Diseases Exacerbate Heart Failure 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.