Bacterial fucosidase enables the production of Bombay red blood cells
Li, T.; Ye, J.; Wang, L.; Zou, L.; Guo, Y.; Hou, L.; Shen, D.; Cai, X.; Huang, H.; Sun, G.; Chen, L.
Show abstract
We present a method to produce H antigen-deficient red blood cells (RBCs) for transfusion to individuals with anti-H antibodies. A fucosidase from bacteria was heterologously expressed efficiently in E. coli and has been demonstrated to completely remove H antigens on the surface of human RBCs in a facile conversion process. The approach we describe here holds promise for making H-deficient RBCs available for a rare population beyond ABO types.
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