Preserved global cerebral blood flow accounts for youthful processing speed in older adults
Yang, F. N.; Xie, L.; Galli, O.; Detre, J. A.; Wolk, D. A.; Rao, H.
Show abstract
Preserved cognitive performance is one of the key contributors to successful aging. The processing speed theory and prefrontal executive theory - are competing theories regarding the general causes of cognitive aging. Here, we used a theoretically-driven framework to investigate the neural correlates of older adults with preserved processing speed. Older adults with youth-like processing speed (SuperAgers) were compared with normal aged adults (TypicalAgers) using neuroimaging methods. Global cerebral blood flow (CBF) accounted for approximately 45% of the variance in processing speed, while neither regional CBF nor other structural measures predicted additional variance. In addition, despite having significantly cortical thinning, SuperAgers still shown comparable global CBF levels with young adults. These results support the global mechanism suggested by processing speed theory and indicate that global CBF may serve as a biomarker of cognitive aging.
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