Comparative study of Dog and Human Lipid Droplet-associated protein (PLIN2)
sahu, G.; Behera, A.; Pandey, V. K.; PS, F.; kumar, M.; Saini, M.; Irungbam, K.
Show abstract
Intracellular lipid droplets (LDs) are vital organelles that store energy, manage oxidative stress, and coordinate cellular signaling. A key protein family associated with LDs is the perilipins, with perilipin 2 (PLIN2) being prominent. This study focuses on a comparative analysis of canine and human PLIN2 to understand their structural and functional similarities. The genomic data for PLIN2 in both species were curated, revealing location, transcripts, exons, and introns. Sequence analysis demonstrated 85% identity between dog and human PLIN2, with conserved residues essential for structural and functional roles. Amino acid composition analysis revealed similarities in charged residues and in stabilizing and destabilizing residues. Despite their structural similarities (72% common secondary structure elements), a 3D comparison revealed significant differences in conformation. Physicochemical properties, including stability indices, were found to be distinct, possibly influencing their interactions. The study highlights the conservation of PLIN2s functional regions, shedding light on its role in protecting LDs from degradation across species.
Matching journals
The top 9 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Ab initio modelling of an essential mammalian protein: Transcription Termination Factor 1 (TTF1) 95%
- Insights into the microevolution of SARS-ACE2 Interactions: In-silico analysis of glycosylation and SNP pattern 95%
- Optimized structure of monoubiquitinated FANCD2 (human) at Lys 561: a theoretical approach 95%
Similar papers in this journal
- Integrated bioinformatics analysis reveals novel key biomarkers and potential candidate small molecule drugs in gestational diabetes mellitus 94%
- Structural Characterization of DNA Binding Domain of Essential Mammalian Protein TTF 1 94%
- A virus that has gone viral: Amino acid mutation in S protein of Indian isolate of Coronavirus COVID-19 might impact receptor binding and thus infectivity 93%
Similar papers in this journal
- An in-silico study of the mutation-associated effects on the spike protein of SARS-CoV-2, Omicron variant 95%
- In silico analysis and in planta production of recombinant ccl21/IL1β protein and characterization of its in vitro anti-tumor and immunogenic activity 95%
- Identification and classification of innexin gene transcripts in the central nervous system of the terrestrial slug Limax valentianus 94%
Similar papers in this journal
- Scanning the RBD-ACE2 molecular interactions in Omicron variant 94%
- Interaction of the spike protein RBD from SARS-CoV-2 with ACE2: similarity with SARS-CoV, hot-spot analysis and effect of the receptor polymorphism 93%
- Mutations on RBD of SARS-CoV-2 Omicron variant result in stronger binding to human ACE2 receptor 93%
Similar papers in this journal
- In Silico Analysis Predicting Effects of Deleterious SNPs of Human RASSF5 Gene on its Structure and Functions 94%
- The Evolutionary History Of The Orexin/Allatotropin Gpcr Family: From Placozoa And Cnidaria To Vertebrata 94%
- Mechanistic insights into the deleterious role of nasu-hakola disease associated TREM2 variants 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.