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External quality assessment of BCR-ABL1 quantification in chronic myeloid leukemia: a pilot interlaboratory study from Russia
2025-11-17
hematology
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BCR-ABL1 is a chimeric oncogene underlying chronic myeloid leukemia (CML) and serves as a key marker for monitoring minimal residual disease. Quantitative RT-qPCR analysis of BCR-ABL1 transcripts enables assessment of molecular response depth and timely detection of treatment failure or resistance. In international practice, the introduction of the International Scale (IS), along with method standardization, has significantly improved the comparability of results between laboratories. Participat...
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