A broad-spectrum, biocompatible, virucidal polymer reduces chikungunya virus in murine models
Macleod, S.-L.; Loo, A. X. Y.; Castillo, M.; Batt, L. J.; Lum, F.-M.; Torres-Ruesta, A.; Ng, L. F. P.; Jones, S. T.
Show abstract
Autochthonous transmission of arboviruses poses significant threats to global health and economies. Yet, no effective antivirals exist. Building on our previous antiviral star-polymer, we designed zwitterionic star-polymers for efficacy in high protein environments. A polymer with 12% positively charged monomer (Zwitterionic Polymer-ZP12) exhibited broad-spectrum, biocompatible antiviral activity against Alphaviridae, Flaviviridae, Herpesviridae, and Picornaviridae. Using murine models for Chikungunya virus (CHIKV) infection, ZP12 treatment (10 mg/kg every 24 hours for 7 days) reduced tissue viral load by 90% 3 days post-infection and significantly alleviated CHIKV-induced joint swelling. Mechanistically, ZP12 downregulated CHIKV-driven immunopathogenesis by reducing viral load and dampening CD4+ T cell and macrophage activation in virus-infected joints. With no current antiviral interventions for these arboviruses, ZP12 represents a promising intervention for combating future pandemics.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- NRF2 activators inhibit influenza A virus replication by interfering with nucleo-cytoplasmic export of viral RNPs in an NRF2-independent manner 95%
- A guanidine-based coronavirus replication inhibitor which targets the nsp15 endoribonuclease and selects for interferon-susceptible mutant viruses 95%
- Biosynthetic proteins targeting the SARS-CoV-2 spike as anti-virals 95%
Similar papers in this journal
- Immunogenicity and protective efficacy of a highly thermotolerant, trimeric SARS-CoV-2 receptor binding domain derivative 95%
- Development of a thermostable and broadly neutralizing pan-sarbecovirus vaccine candidate 94%
- Challenges for targeting SARS-CoV-2 proteases as a therapeutic strategy for COVID-19 92%
Similar papers in this journal
- Emergence of transmissible SARS-CoV-2 variants with decreased sensitivity to antivirals in immunocompromised patients with persistent infections 94%
- Glycan remodeled erythrocytes facilitate antigenic characterizationof recent A/H3N2 influenza viruses 93%
- A stabilized MERS-CoV spike ferritin nanoparticle vaccine elicits robust and protective neutralizing antibody responses 93%
Similar papers in this journal
- Combinations of approved oral nucleoside analogues confer potent suppression of alphaviruses in vitro and in vivo 95%
- The human α-defensin-derived peptide HD5(1-9) inhibits cellular attachment and entry of human cytomegalovirus. 93%
- Identification of novel Ebola virus inhibitors using biologically contained virus 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.