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Impact of Standard versus Extended Natalizumab Dosing and Treatment Withdrawal on Relapse, Disability, MRI Activity and Safety in Adults with MS: A Systematic Review and Meta-Analysis

2025-10-22 neurology Title + abstract only
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BackgroundNatalizumab is a high-efficacy therapy for RRMS. While EID may reduce PML risk, critical gaps persist in understanding post-cessation outcomes, posing urgent clinical challenges for neurologists discontinuing treatment. ObjectivesTo compare efficacy/safety of natalizumab SID vs. EID and quantify relapse/disability risk after cessation in adults with RRMS. MethodsWe conducted a systematic review/meta-analysis (PROSPERO: CRD420251103014) following PRISMA guidelines. We searched MEDLINE...

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