Fatty Acid Pathways Regulate Thermal Nociception in Caenorhabditis elegans
Abdollahi, M.; Beaudry, F.
Show abstract
Chronic pain remains a major unmet medical challenge, and lipid signaling pathways have emerged as key modulators of nociception. Using Caenorhabditis elegans as a genetically tractable model, we investigated how fatty acid composition influences thermal avoidance behavior. Mutant strains lacking functional desaturase enzymes (elo-1, fat-1, fat-2, fat-3, fat-4, fat-6/fat-7), and consequently depleted in polyunsaturated fatty acids (PUFAs) such as arachidonic acid, displayed significantly reduced sensitivity to noxious heat compared to wild-type animals. These findings indicate that intact PUFA biosynthesis is essential for normal thermal nociception in C. elegans. Given that arachidonic acid is a precursor of endocannabinoids (AEA and 2-AG) known to modulate TRPV1-dependent pain signaling, our results suggest that a conserved lipid-based mechanism regulates heat avoidance in nematodes. This study establishes a functional link between fatty acid metabolism and nociceptive behavior, providing a powerful platform to explore metabolic modulation of pain pathways.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Microsporidia infection alters C. elegans lipid levels 93%
- Behavioral and genetic analysis of the effects of the psychedelic 2,5-dimethoxy-4-iodoamphetamine (DOI) in C. elegans 93%
- A Familial Alzheimers Disease Associated Mutation in Presenilin-1 Mediates Amyloid-Beta Independent Cell Specific Neurodegeneration 93%
Similar papers in this journal
Similar papers in this journal
- Cold-sensing TRP channels and temperature preference modulate ovarian development in the model organism Drosophila melanogaster 92%
- Analysis of the Toll and spaetzle genes involved in Toll path-way-dependent antimicrobial gene induction in the red flour beetle, Tribolium castaneum (Coleoptera: Tenebriodae) 91%
- BRAF controls the effects of metformin on neuroblast cell divisions in C. elegans 91%
Similar papers in this journal
- Estrogen Dependent Variation in the Contributions of TRPM4 and TRPM5 to Fat Taste 91%
- Characterization of an Agarophyton chilense oleoresin containing PPARγ natural ligands with insulin-sensitizing effects in a C57BL/6J mouse model of diet-induced obesity and antioxidant activity in Caenorhabditis elegans. 91%
- Differential and synergistic effects of low birth weight and Western diet on skeletal muscle vasculature, mitochondrial lipid metabolism and insulin signaling in male guinea pigs 90%
Similar papers in this journal
- Studies on CRMP2 SUMOylation-deficient transgenic mice identify sex-specific NaV1.7 regulation in the pathogenesis of chronic neuropathic pain 92%
- TRPM3 as novel target to alleviate acute oxaliplatin-induced peripheral neuropathic pain 92%
- Inhibition of TRPV1 and TRPA1 by mosquito and mouse saliva 91%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.