Placental immune factors change during the first half of healthy pregnancy
Obolenskaya, M. Y.; Lykhenko, O.; Kukuruza, Y.; Martynenko, V.; Poliakov, Y.; Martsenyuk, O.; Bezguba, V.; Huppertz, B.
Show abstract
During gestation, the human placenta develops as a fetal organ in direct contact with maternal cells and tissues. Most pregnancy complications, such as preeclampsia and fetal growth restriction, have their roots early in pregnancy, most probably in dysregulation of placental development and/or disturbances in the interaction with maternal (immune) cells. Here, we applied an integrative analysis of open-access gene expression data on the human placenta, comparing expression levels between the first and second trimesters of healthy pregnancy, with a focus on differentially expressed genes related to immune processes. The holistic approach of our study revealed differentially expressed genes involved in the recognition and elimination of potential PAMPs and DAMPs, transendothelial cell migration, cytokine production, transplacental IgG transport, and maintenance of immune tolerance during the transition from the first to the second trimester of placental development. Most DEGs show an increased expression. Only a few genes, DEFB1, SLPI, and LCN2, which encode antimicrobial proteins, homeostatic chemokines, and a pleiotropic PAEP that maintains tolerance, display maximal expression in the first trimester, followed by further down-regulation. The cell types deconvolutions revealed the typical representation of placental cells.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Analysis of commonly expressed genes between first trimester fetal heart and placenta cell types in the context of congenital heart disease 95%
- Inflammatory biomarkers in pregnant women with COVID-19: a retrospective cohort study 94%
- Meta-analysis of transcriptomes of SARS-Cov2 infected human lung epithelial cells identifies transmembrane serine proteases co-expressed with ACE2 and biological processes related to viral entry, immunity, inflammation and cellular stress. 93%
Similar papers in this journal
- Preterm birth is associated with immune dysregulation which persists in infants exposed to histologic chorioamnionitis: a descriptive study 93%
- Systems-Level Proteomics Evaluation of Microglia Response to Tumor-Supportive Anti-inflammatory Cytokines 92%
- Soluble immune checkpoints are dysregulated in COVID-19 and heavy alcohol users with HIV infection 92%
Similar papers in this journal
- Placental transcription profiling in 6-23 weeks’ gestation reveals differential transcript usage in early development 94%
- Decreased levels of soluble Developmental endothelial locus-1 are associated with thrombotic microangiopathy in pregnancy 93%
- Genome-wide association study of COVID-19 Breakthrough Infections and genetic overlap with other diseases: A study of the UK Biobank 91%
Similar papers in this journal
- Minimal mRNA uptake and inflammatory response to COVID-19 mRNA vaccine exposure in human placental explants 93%
- Metabolic Flexibility and Energy Substrate Utilization Regulate Contractility in the Human Myometrium 92%
- Single-cell transcriptional landscapes of bovine peri-implantation development 92%
Similar papers in this journal
- O-GlcNAc transferase contributes to sex-specific placental deregulation in gestational diabetes 94%
- SARS-CoV-2 infection disrupts syncytial and endothelial integrity and alters PLGF levels in the placenta 94%
- Single-cell sequencing of trophoblasts in preeclampsia and chemical hypoxia in BeWo b30 cells reveals EBI3, COL17A1, miR-27a-5p, and miR-193b-5p as hypoxia-response markers 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.