Effects of Continuous Oral Intake of DR.ERGO(R) Ergothioneine Capsules on Skin Status: A Randomized, Double-Blind, Placebo-Controlled Trial

BackgroundErgothioneine (ergothioneine) is a naturally occurring antioxidant with emerging evidence supporting its role in cellular protection and anti-aging. However, clinical data on its cosmetic benefits remain limited. ObjectiveTo evaluate the effects of daily oral supplementation with DR.ERGO(R) ergothioneine capsules on skin condition in healthy women reporting signs of skin aging. MethodsIn this 8-week, randomized, double-blind, placebo-controlled trial, 66 women aged 35-59 years were assigned to receive either DR.ERGO(R) ergothioneine (30 mg/day) or placebo. Skin parameters including melanin index, erythema index, glossiness, elasticity (R2, R5, R7), spot count, wrinkle count were evaluated at baseline, 4 weeks, and 8 weeks. ResultsCompared to placebo, the DR.ERGO(R) ergothioneine group showed significantly greater improvements in melanin and erythema reduction, skin glossiness, elasticity, and wrinkle and spot reduction (all p < 0.01). No adverse events were reported. ConclusionContinuous oral intake of DR.ERGO(R) ergothioneine significantly improved skin aging parameters, with excellent safety and tolerability. These findings suggest DR.ERGO(R) ergothioneine may serve as an effective oral anti-aging agent.