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Evaluating MRI-Confirmed Relapses as a Novel Primary Endpoint in Multiple Sclerosis Trials

2025-10-13 neurology Title + abstract only
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BackgroundClinically defined relapses are the traditional primary endpoint of randomized control trials (RCTs) in multiple sclerosis (MS), yet a substantial proportion lack new inflammatory lesions. Confirming relapses with brain and spinal cord MRI to distinguish relapses with active MRI (RAM) from acute clinical events with stable MRI (ACES) may provide a more sensitive primary outcome for future trials. ObjectiveTo estimate RAM and ACES rates in MS trials and evaluate the impact on statistic...

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