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IgG4 Neutralization and Sustained Total IgG Fc-Effector Functions Following Repeated SARS-CoV-2 mRNA Vaccination

2025-10-02 infectious diseases Title + abstract only
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Detailed characterization of the antibody profile induced by SARS-CoV-2 mRNA vaccines has shown that repeat dosing boosts all IgG subclasses, with a notable emergence of antigen-specific IgG4 antibodies. While the IgG4 subclass is traditionally associated with limited Fc-effector functions, its role in SARS-CoV-2 mRNA vaccine-induced immunity remains unclear. This study tracked IgG subclass dynamics, IgG Fc-mediated functions and neutralization following immunization with two or three doses of m...

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