Back

CYP2D6 variants in amyotrophic lateral sclerosis: an association study of risk and survival

2025-10-06 neurology Title + abstract only
View on medRxiv
Show abstract

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder with limited therapeutic options. Riluzole remains the only widely available treatment in ALS, yet its benefits are modest and highly variable across patients. Genetic variation in cytochrome P450 2D6 (CYP2D6), a major enzyme in drug metabolism, detoxification of environmental toxins, and biotransformation of endogenous transmitters, has been implicated as a risk factor in neurodegenerative diseases. It has been obse...

Predicted journal destinations

1
Movement Disorders
49 training papers
Top 1.0% 11.3%
2
Brain
69 training papers
Top 0.7% 10.5%
3
Annals of Neurology
43 training papers
#1 7.5%
4
npj Parkinson's Disease
35 training papers
Top 0.9% 7.5%
5
Brain Communications
79 training papers
Top 2% 6.2%
6
Journal of Neurology, Neurosurgery & Psychiatry
26 training papers
Top 0.2% 5.7%
7
Alzheimer's & Dementia
84 training papers
Top 3% 5.7%
8
Neurobiology of Aging
29 training papers
Top 0.2% 4.8%
9
Scientific Reports
701 training papers
Top 69% 3.7%
10
Neurology
38 training papers
Top 4% 2.9%
11
Journal of Neurology
22 training papers
Top 0.8% 2.7%
12
Nature Communications
483 training papers
Top 33% 2.7%
13
Parkinsonism & Related Disorders
16 training papers
Top 1% 1.9%
14
eBioMedicine
82 training papers
Top 2% 1.9%
15
Frontiers in Neurology
74 training papers
Top 8% 1.9%
16
PLOS ONE
1737 training papers
Top 95% 1.5%
17
Annals of Clinical and Translational Neurology
22 training papers
Top 2% 1.5%
18
European Journal of Neurology
20 training papers
Top 3% 1.3%
19
eLife
262 training papers
Top 40% 1.1%
20
Alzheimer's Research & Therapy
31 training papers
Top 4% 1.1%
21
Epilepsia
27 training papers
Top 3% 1.1%
22
NeuroImage: Clinical
77 training papers
Top 11% 0.9%
23
Journal of Alzheimer’s Disease
23 training papers
Top 3% 0.9%
24
Journal of Alzheimer's Disease
31 training papers
Top 5% 0.9%
25
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
28 training papers
Top 5% 0.7%
26
Human Brain Mapping
53 training papers
Top 11% 0.7%
27
Molecular Psychiatry
84 training papers
Top 10% 0.7%
28
Multiple Sclerosis Journal
15 training papers
Top 3% 0.7%
29
EMBO Molecular Medicine
15 training papers
Top 1% 0.7%