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Hemodynamic Oscillations in Mild TBI During Postural Change: An fNIRS Pilot Study

Kim, C.; Carrillo, A. G.; Sunar, U.

2025-09-26 neurology
10.1101/2025.09.25.25336687 medRxiv
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We demonstrate that low-frequency oscillations (LFOs) in cerebral hemodynamics, measured by frequency-domain functional near-infrared spectroscopy (FD-fNIRS), reflect altered cerebral hemodynamic oscillations in mild traumatic brain injury (mTBI). In a pilot study of two mTBI and 13 healthy subjects undergoing head-of-bed positional changes, we analyzed total hemoglobin concentration (THC), oxyhemoglobin (HbO), and deoxyhemoglobin (Hb) dynamics using spectral and time-frequency analyses. mTBI measurements exhibited significantly larger postural changes in THC ({Delta}THC = 9.49 {micro}M) compared to controls ({Delta}THC = 1.03 {micro}M). LFO power was consistently elevated in mTBI across all slow bands (0.01-0.2 Hz), particularly in the Slow-5 band (0.01-0.027 Hz), suggesting dysregulated cerebral vasomotion. Continuous wavelet transform (CWT) confirmed persistent LFO amplification during and after postural transitions. These findings indicate that THC-based LFO measures may serve as early, non-invasive biomarkers of cerebral autoregulatory impairment in mTBI.

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