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Meningovascular inflammation in cerebral amyloid angiopathy-related cortical superficial siderosis

2025-09-25 neurology Title + abstract only
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The role of inflammation in cortical superficial siderosis (cSS), a marker of cerebral amyloid angiopathy (CAA) linked to high hemorrhage risk, is unclear. We examined 14 patients with cSS using 3T post-contrast vessel wall MRI (VWI) and CSF analysis. Although only 31% met current CAA-ri criteria, 86% showed vessel wall enhancement or sulcal hyperintensities near cSS, frequently extending beyond. Four patients with follow-up VWI demonstrated corticosteroid-responsive regression of inflammation. ...

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