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Aerobic Exercise Training Elevates Circulating sRAGE via Modulation of Sheddase Regulation in Adults with Type 2 Diabetes
2025-09-12
endocrinology
Title + abstract only
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ObjectiveSoluble receptors for advanced glycation end-products (sRAGE) and Toll-like receptor 4 (sTLR4) function as decoy receptors that blunt proinflammatory signaling in metabolic disease. This study examined the effects of 12 weeks of aerobic exercise (AE) training on circulating sRAGE, sTLR4, and associated skeletal muscle sheddase regulators in adults with type 2 diabetes mellitus (T2DM). MethodsThirty-three sedentary adults with T2DM (age 40-75 yrs) were randomized to AE (n=20) or control...
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