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Health Economic Analysis Plan for the Hospital Acquired Pneumonia PrEveNtion (HAPPEN) study: A multi-centre randomised control trial exploring the effectiveness of improving the frequency and quality of oral care in reducing the incidence of pneumonia.

Sharma, P.; White, N. M.; Graves, N.; Mitchell, B.

2025-08-27 infectious diseases
10.1101/2025.08.25.25333724 medRxiv
Show abstract

The Hospital-acquired Pneumonia Prevention (HAPPEN) study is a multi-site, stepped wedge cluster randomised trial evaluating the impacts of improving oral care among adult patients to reduce the incidence of non-ventilator, hospital-acquired pneumonia (HAP). This document is the Health Economics Analysis Plan (HEAP) for evaluating the cost-effectiveness of the intervention compared with usual care. The trial was preregistered on the Australian and New Zealand Clinical Trials registry (ACTRN12624000187549) and is funded by the Medical Research Future Fund (MRF2022645). A copy of the study protocol and a signed version of this plan are available on request from the corresponding author (BM)

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