The Gwangju Alzheimer's & Related Dementias (GARD) Cohort: Over a Decade of Korea's Largest Longitudinal Multimodal Study
Choi, K. Y.; Kang, S.; Cook, S.; Li, D.; Choi, Y. Y.; Seo, E. H.; Han, X.; Park, J. E.; Lee, S.; Lee, S.; Chung, J. Y.; Chong, A.; Choi, S.-M.; Ha, J.-M.; Song, M. K.; Lee, J. S.; Choo, I. H.; Kim, B. C.; Kim, H.; Farrer, L. A.; Gim, J.; Jun, G. R.; Lee, K. H.
Show abstract
INTRODUCTIONAlzheimers disease (AD) is a major public health concern in Korea, with a high prevalence among older adults. A community-based longitudinal study is essential for tracking disease progression, identifying biomarkers, and developing targeted prevention and treatment strategies. The Gwangju Alzheimers and Related Dementias (GARD) cohort was established to address these needs through a multimodal approach. METHODSParticipants aged [≥]60 undergo comprehensive clinical evaluations, neuroimaging, and biospecimen collection for multi-omics analyses (genomics, transcriptomics, proteomics, microbiome) at baseline and systematic follow-up visits. RESULTSFrom over 17,000 screened individuals, 12,877 were enrolled. Baseline diagnoses include 5,995 cognitively unimpaired (CU), 4,025 mild cognitive impairment (MCI), and 1,026 AD dementia. The resource includes MRI scans (n=10,843) and extensive multi-omics data: genomic (n=10,775), proteome (n=116), and microbiome (n=595). DISCUSSIONThe integrated GARD dataset provides a powerful and scalable resource for identifying novel biomarkers, understanding disease heterogeneity, and advancing precision medicine for AD.
Matching journals
The top 2 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- APOE-stratified genome-wide association study suggests potential novel genes for late-onset Alzheimer’s disease in East-Asian descent 97%
- Inferring Alzheimer’s disease pathologic traits from clinical measures in living adults 96%
- Examining a Preclinical Alzheimer’s Cognitive Composite for Telehealth Administration, the tPACC, for Reliability between In-Person and Remote Cognitive Testing with Neuroimaging Biomarkers 96%
Similar papers in this journal
- Quantitative longitudinal predictions of Alzheimer's disease by multi-modal predictive learning 97%
- Association between motor task acquisition and hippocampal atrophy across cognitively unimpaired, amnestic Mild Cognitive Impairment, and Alzheimer’s disease individuals 95%
- Targeted Serum Metabolomic Profiling and Machine Learning Approach in Alzheimer’s Disease using the Alzheimer’s Disease Diagnostics Clinical Study (ADDIA) Cohort 95%
Similar papers in this journal
- Polygenic effects on the risk of Alzheimer’s disease in the Japanese population 97%
- Plasma biomarker profiles and the correlation with cognitive function across the clinical spectrum of Alzheimer’s disease 97%
- White matter integrity is associated with cognition and amyloid burden in older adult Koreans along the Alzheimer’s disease continuum 96%