Effect of acute elevated magnesium on bursting activity and information-processing dynamics in cortical cultures
LaGrange, K. G. H.; Varley, T. F.; O'Shea, L. F.; Fitzpatrick, J. G.; Cummings, S. E.; Beggs, J. M.
Show abstract
Magnesium (Mg2+) plays a significant role in hippocampal memory and learning and is implicated in a variety of neurological disorders, such as migraine. Despite this crucial role Mg2+ has on brain health, its effect on the dynamics of networks of neurons is still not fully understood. This study investigates the impact of several doses of elevated extracellular Mg2+ on organotypic cultures. Cultures were recorded on a 512-microelectrode array and analyzed using the burstiness index (BI), the rate of network-wide bursts relative to other neuronal activity. We also use a suite of information theoretic measures to further establish the role Mg2+ plays in the brain. Elevated Mg2+ is found to have a dose-dependent increase on BI caused by a loss of network activity not contained within a burst or high firing rate activity. Information dynamics further show that the network experiences a loss of entropy and an increase in time-reversibility, connectivity, and transfer of redundant information. These factors indicate that Mg2+ causes a loss of complex activity and an increase in highly integrated, constant dynamics. This lays the groundwork for a deeper examination of the role Mg2+ plays in learning, memory and treating neurological disorders.
Matching journals
The top 11 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Visualization of Incrementally Learned Projection Trajectories for Longitudinal Data 93%
- Static magnetic stimulation induces structural plasticity at the axon initial segment of inhibitory cortical neurons 92%
- Novel Adult Cortical Neuron Processing and Screening method illustrates Sex- and Age-dependent effects of pharmaceutical compounds 92%
Similar papers in this journal
- Comparative study between radiofrequency-induced and muscimol-induced inhibition of cultured networks of cortical neuron 92%
- Phenotypic screening using waveform analysis of calcium dynamics in primary cortical cultures 92%
- The effect of dopamine transporter blockade on optical self-stimulation: behavioral and computational evidence for parallel processing in brain reward circuitry 92%
Similar papers in this journal
- Developmental effect of RASopathy mutations on neuronal network activity on a chip 92%
- Plasticity impairment alters community structure but permits successful pattern separation in a hippocampal network model 92%
- Structural and functional alterations associated with the LRRK2 G2019S mutation revealed in structured human neural networks 91%
Similar papers in this journal
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.