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A Multimodal Evaluation of Transcranial Photobiomodulation in Mild Cognitive Impairment: Cognitive, Metabolic, and Neuroimaging Outcomes of a Pilot Randomized Control Trial

2025-08-24 pharmacology and therapeutics Title + abstract only
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INTRODUCTIONMild cognitive impairment (MCI), a prodromal stage of Alzheimers disease and related dementias (ADRD), represents a critical window for intervention. Although mitochondrial dysfunction is increasingly implicated in neurodegeneration, most therapies target downstream protein aggregation. Transcranial photobiomodulation (tPBM) delivers near-infrared light to enhance mitochondrial respiration. We hypothesized that tPBM in MCI would be safe, feasible, and associated with improvements in ...

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