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The modified 30-second chair stand test (m-30s-CST) is more sensitive than handgrip strength in detecting muscle strength changes and predicting physical performance and mortality in hospitalized geriatric patients

Sipers, W.; Ensink, I.; Rothbauer, M.; Shannon, R.; Merry, A.

2025-08-21 geriatric medicine
10.1101/2025.08.18.25333644 medRxiv
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ObjectivesTo compare the modified-30s-Chair-Stand-Test (m-30s-CST) with handgrip strength (HGS) in measuring muscle strength in acutely ill geriatric patients. The aim of this study is to compare the responsiveness and predictive value of the m-30s-CST and HGS for physical performance and two-year mortality in hospitalized geriatric patients MethodsResponsiveness of the m-30s-CST and HGS was assessed in 92 patients (mean age 84{+/-}6 y, 53.5% female) by comparing the performance at hospital admission and the day before discharge. These changes were then compared with changes in the ADL-Barthel-Index (ADL-BI) and Short Physical Performance Battery (SPPB). ResultsThe number of repetitions on the m-30s-CST increased significantly during hospitalization in patients who improved on ADL-BI (n=43) and SPPB (n= 33) and did not change in those who remained stable or worsened (ADL-BI: n= 32 and SPPB: n= 26). There was no significant change in HGS in either patients who improved on respectively ADL-BI (n=43) and SPPB (n=41), nor in those who remained stable or worsened (ADL-BI: n=31 and SPPB: n= 34). Two-year mortality was significantly higher in geriatric patients with low performance on the m-30s-CST. HGS was not associated with 2-year mortality. ConclusionThe m-30s-CST is superior to HGS for assessing changes in muscle strength, serves as a better proxy for physical performance, and is a strong predictor of two-year mortality in hospitalized geriatric patients.

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