Non-vocal motor deficits in a transgenic mouse model linked to stuttering disorders
Millwater, M.; Weinhold, M.; Bragg, C.; Kaur, H.; Zhang, R.; SheikhBahaei, S.
Show abstract
Stuttering is a neurodevelopmental disorder characterized by involuntary disruptions in speech. In addition, non-vocal motor impairments are reported in some individuals who stutter. Although its precise cause remains unknown, mutations in lysosomal trafficking proteins (such as GNPTAB) have been identified in a subgroup of people who stutter. To understand the functional significance of these mutations, transgenic Gnptab mice have been developed, and as expected, these mice exhibit vocal deficits throughout developmental stages. However, whether these mice also display non-vocal motor impairments is unknown. Our data reveal deficits in the breathing, locomotion, and grooming behaviors of the Gnptab mouse model, outlining a broader phenotype linked to GNPTAB mutations in stuttering. These findings suggest that lysosomal dysfunction may disrupt astrocyte-regulated motor circuits, affecting both vocal and non-vocal rhythmic behaviors that are central to stuttering neurophysiological symptoms.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Coadaptation of the chemosensory system with voluntary exercise behavior in mice 93%
- Impaired trigeminal control of ingestive behavior in the Prrxl1- / - mouse is associated with a lemniscal-biased orosensory deafferentation 92%
- GluD1 knockout mice with a pure C57BL/6N background show impaired fear memory, social interaction, and enhanced depressive-like behavior 92%
Similar papers in this journal
- A Novel Role for Phospholamban in the Thalamic Reticular Nucleus 92%
- Use of RHO GTPase by L1 GABAergic neurons in frontal cortex and L6 glutamatergic neurons in prefrontal cortex differentiates states of unconsciousness 92%
- The Innate Immune Toll-Like Receptor-2 modulates the Depressogenic and Anorexiolytic Neuroinflammatory Response in Obstructive Sleep Apnoea 91%
Similar papers in this journal
- Insulin-like growth factor-2 does not improve behavioral deficits in mouse and rat models of Angelman Syndrome 93%
- Hyperthermia elevates brain temperature and improves behavioural signs in animal models of Autism spectrum disorder. 89%
- Neuroanatomy and Behaviour in Mice with a Haploinsufficiency of AT-Rich Interactive Domain 1B (ARID1B) Throughout Development 89%
Similar papers in this journal
- Obesity alters Ace2 and Tmprss2 expression in lung, trachea, and esophagus in a sex-dependent manner: Implications for COVID-19 92%
- Effect of caldesmon mutations in the development of zebrafish embryos. 88%
- The frequency-dependent effect of electrical fields on the mobility of intracellular vesicles in astrocytes 88%
Similar papers in this journal
- Angle-angle diagrams in the assessment of locomotion in persons with multiple sclerosis: A preliminary study 87%
- Serotonin signaling in the enteric nervous system and connection to autism spectrum disorder: a translational mathematical model 87%
- Are Electromyography data a fingerprint for patients with cerebral palsy (CP)? 86%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.