Elaboration and validation of R-LAST, a screening tool to detect CDD in acute right hemisphere stroke

BackgroundThe role of the right hemisphere in language use and interpretive abilities has become clearer through studies describing sequelae in patients with right hemisphere stroke (RHS). Between 50% and 78% of stroke survivors with RHS experience communication disorders, a condition recently termed "apragmatism" by a group of experts. Apragmatism can negatively impact individuals personal lives and overall quality of life. ObjectiveTo develop and validate a bedside cognitive and communication screening tool for features of apragmatism in prospective patients with right stroke, called the Right Language Screening Test (R-LAST), which is simple, rapid, and suitable for emergency settings. Patients and methodsR-LAST consists of seven subtests and twelve items. We report its internal and external validity and inter-rater reliability. We validated the scale by prospectively administering it to 300 patients admitted to two stroke units with confirmed right stroke, as well as to 94 stabilized patients with and without cognitive-communication disorders, using the MEC B as a reference. ResultsInternal validity demonstrated no redundancy with a Pearson coefficient less than 0.8. The internal consistency of the 12 items was questionable, indicated by a Cronbachs alpha of 0.62. External validation against MEC B revealed a sensitivity of 0.84 and a specificity of 0.82. Inter-rater agreement was nearly perfect (ICC 0.993). The average time needed to complete R-LAST was 3 minutes and 52 seconds. ConclusionR-LAST could enable rapid and reliable detection of apragmatism in the acute phase of stroke, which could lead to timely referrals to speech-language therapists and ensure timely rehabilitation. This comprehensively validated cognitive-communication disorders rating scale is simple and rapid, making it a useful tool for bedside evaluation of acute stroke patients in routine clinical practice. Clinical Trial RegistrationUnique Identifier: NCT03622606 URL: https://clinicaltrials.gov/study/NCT03622606?term=R-LAST&rank=1