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Vector-derived Cadherin Mimicry in Pemphigus Vulgaris: A Proposed Model Linking HLA-DRB1*04:02/14:01 Genotype with Environmental Exposure
2025-08-08
dermatology
Title + abstract only
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Pemphigus vulgaris (PV) is a life-threatening autoimmune blistering disease caused by pathogenic autoantibodies targeting the desmosomal cadherins desmoglein 3 (DSG3) and desmoglein 1 (DSG1), essential for cell-cell adhesion. Although the role of these autoantibodies in disease pathogenesis is well established, the mechanisms initiating the autoimmune response remain unclear. A strong genetic association has been identified between PV and specific HLA class II alleles, particularly HLA-DRB1*04:0...
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