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LRRK2 p.G2385R and p.R1628P Variants in a Multi-Ethnic Asian Parkinson's Cohort: Epidemiology and Clinical Insights

2025-08-08 neurology Title + abstract only
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The frequency and clinical impact of LRRK2 p.G2385R and p.R1628P risk variants in Parkinsons disease (PD) remain uncertain, particularly across different Asian populations. We genotyped 3,058 multi-ethnic Malaysian PD patients, performed detailed phenotyping in 185, and analyzed disease progression in 635 using longitudinal Clinical Impression of Severity Index for PD scores. p.G2385R was largely confined to Chinese (8.2%), while p.R1628P occurred in mixed ancestry (11.0%), Chinese (8.3%), Malay...

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