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Data-driven modelling of tau pathology reveals distinct progressive supranuclear palsy subtypes
2025-08-05
pathology
Title + abstract only
View on medRxiv
Show abstract
Progressive supranuclear palsy (PSP) is a heterogeneous neurodegenerative disease characterised by the accumulation of misfolded 4-repeat tau within neurones and glial cells. There is limited longitudinal data on pathologically confirmed PSP patients with phenotypes other than classical Richardsons syndrome (RS), and the pathomechanisms responsible for the broad variability in clinical phenotype and progression are not well understood. An unresolved question in this context is whether distinct s...
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