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Dorsal Attention Network as a Convergent Hub of Diverse Non-pharmacological Interventions Preserving Functional Gradients and Cognition in Aging

Jin, X.; Tang, W.; Zheng, Z.; Wang, P.; Zhu, X.; Cui, X.; Yin, S.; Lv, Z.; Xie, H.; Li, R.; Li, J.

2025-07-31 neuroscience
10.1101/2025.07.26.666919 bioRxiv
Show abstract

Non-pharmacological interventions (NPIs) in aging neuroscience have largely focused on intervention-specific regional effects, with limited understanding of generalizable network-level mechanisms. Here, adopting a previously unexplored gradient-based perspective of functional brain organization, we analyzed an NPI dataset involving four interventions in older adults (training/control group: n = 112/59). NPIs led to strengthened intra-network functional integration and maintained macroscale gradient architecture. Virtual lesion analyses identified the dorsal attention network (DAN) as a key contributor to gradient maintenance. Critically, enhanced post-intervention DAN connectivity was associated with maintained gradient structure and improved global cognition. These findings establish a unifying framework in which the DAN acts as a convergent hub through which diverse NPIs preserve functional brain organization and attenuate cognitive aging.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.