Fever induces long-term synaptic enhancement and protects learning in an accelerated aging model
Glebov, O. O.; Du, F.; Wan, Q.
Show abstract
Physiological impact of fever in the brain remains poorly understood. Here, we demonstrate that induction of fever by yeast injection in rats (N=9) and by whole-body hyperthermia in mice (N=7) triggers structural synaptic enhancement in the prefrontal cortex involving AMPA-type glutamate receptor signalling and protein translation (N=6). Repeated fever induction in juvenile rats (N=9) results in synaptic strengthening that persists into adulthood, mitigating learning deficits and synaptic loss in a D-galactose model of accelerated aging (N=11). Our results show how common environmental conditions may shape brain function in the long-term via synaptic plasticity, warranting further exploration of thermal treatment for cognitive protection in aging.
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