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Epidemiological analysis of all vena cava filter placement over 9 years in Brazil: trends and mortality rates in a population of over 200 million

Bueno, C. S.; Santos, H. M.; Ferreira, J. F. C. d. P.; Ponte, B. J.; Portela, F. S. O.; da Silva, M. F. A.; Teivelis, M. P.; Fioranelli, A.; Wolosker, N.

2025-07-08 surgery
10.1101/2025.07.07.25331036 medRxiv
Show abstract

BackgroundVenous thromboembolism (VTE) is a major global health concern, with inferior vena cava filters (VCFs) serving as an alternative to anticoagulation in high-risk patients. Brazils VCF trends remain understudied, particularly in its dual public-private healthcare system. This database study allows a broad overview of the Brazilian healthcare landscape. MethodsThis retrospective nationwide analysis used Brazilian public (SUS/TabNet) and private (ANS/D-TISS) healthcare databases (2015-2023) to assess VCF placement rates, regional disparities and in-hospital mortality. Data included 21,630 procedures, analyzed via generalized linear models (Gamma/Poisson distributions). ResultsThe private system performed 57% of VCFs (12,323) despite covering only 25% of the population, with a 4.25-fold higher procedure rate per capita than the public system (29.45 vs. 6.42 per million). Women accounted for 57.8% of recipients. The Southeast region dominated (70% private, 40.5% public), while the North and Midwest had the lowest rates. Mortality rates were comparable (public 6.7% vs. private 7.4%, p = 0.066), peaking during COVID-19. Procedure volumes rose 140% over 9 years, contrasting with declining U.S. trends post-FDA restrictions. Conclusions: Brazils VCF use reflects systemic inequities, with private-system overrepresentation and regional gaps. This study enables unprecedented insights into large-scale VCF implementation across diverse healthcare subsystems.

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