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Investigating the causal effect of potential therapeutic agents for colorectal cancer prevention: a Mendelian randomization analysis

2025-07-07 epidemiology Title + abstract only
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BackgroundConventional observational studies have identified several potential therapeutic agents that may lower risk of colorectal cancer development. However, these studies are susceptible to unmeasured and residual confounding and reverse causation, undermining robust causal inference. MethodsWe used Mendelian randomization (MR), a genetic epidemiological method that can strengthen causal inference, to evaluate the effect of previously reported therapeutic agents on colorectal cancer risk, i...

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