Electrocardiographic abnormalities and Cardiovascular outcomes in systemic autoimmune rheumatic diseases: A scoping review protocol

ObjectiveThis Scoping review seeks to carry out a global mapping of the literature on electrocardiographic abnormalities and major adverse cardiovascular outcomes in patients with systemic autoimmune rheumatic diseases. IntroductionSystemic autoimmune rheumatic diseases (SARD) constitute a heterogeneous group of inflammatory disorders. Cardiovascular involvement in SARD may result from the involvement of different structures, including the electrical system, leading to rhythm and conduction disturbances. Identifying electrocardiographic changes associated with major adverse cardiovascular events (MACE), such as heart failure, myocardial and cerebral ischemia, may contribute to increased awareness, better management strategies, and potential reduction in morbidity and mortality. Inclusion criteriaThis review will include articles describing electrocardiographic changes and the occurrence of MACE in adults with autoimmune rheumatic diseases, except type 1 diabetes. MethodsThe protocol will follow the JBI methodology, and the writing will follow the PRISMA-ScR guidelines. The search strategy will be carried out in the PubMed, BVS, CENTRAL, Embase, Periodicos CAPES and Google Scholar databases, including publications from the last 10 years without language restrictions. The Covidence platform will be used in the selection, identification of duplicates, two-stage review and data extraction, conducted by independent reviewers. The data will be analyzed according to the question and objectives of the scoping review, and the results will be presented in tables, charts, and a narrative summary. Final considerationsIt is expected that the proposed scoping review protocol will present the general state of scientific evidence and identify gaps to be clarified on the topic.