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Machine Learning Identifies Microbiome and Clinical Predictors of Sustained Weight Loss Following Prolonged Fasting
2025-06-26
nutrition
Title + abstract only
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Prolonged fasting may benefit metabolic health, but data in healthy individuals remain limited. We performed a randomized, waitlist-controlled study (LEANER study), with 38 healthy participants completing a 5-day-fasting intervention with 12-week follow-up. Fasting acutely lowered body mass index (BMI), via fat mass loss. These changes partially persisted at follow-up. Fasting altered the gut microbiome composition and induced metabolite shifts in plasma and feces. Changes to gut microbiome alph...
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