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Metabolic modeling reveals determinants of synbiotic efficacy in a human intervention trial.

2025-06-25 nutrition Title + abstract only
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Prebiotic, probiotic, and combined (synbiotic) interventions often show variable outcomes across individuals, driven by complex interactions between introduced biotics, the endogenous microbiota, and the host diet. Predicting individual-specific success or failure of probiotic and prebiotic therapies remains a major challenge. Here, we leverage microbial community-scale metabolic models (MCMMs) to forecast probiotic engraftment and microbiota-mediated short-chain fatty acid (SCFA) production in ...

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