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Succinate dehydrogenase expression and activity: A potential molecular fingerprint with metabolism-rewiring properties and clinical impact in undifferentiated pleomorphic sarcomas

2025-06-23 oncology Title + abstract only
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Undifferentiated pleomorphic sarcoma (UPS) remains one of the most clinically aggressive and poorly characterized soft tissue sarcoma (STS) subtypes. To uncover distinctive molecular traits for UPS, a multi-omics analysis of UPS compared to leiomyosarcoma (LMS), and liposarcoma (LPS) was performed. Transcriptomic profiling revealed that UPS exhibits overexpression of genes encoding succinate dehydrogenase (SDH) subunits, particularly SDHB, SDHC, and SDHD, distinguishing it from LMS and dediffere...

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