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Non-cell autonomous control of presynaptic remodeling by the hypothalamic autophagy/NPY axis

Cazzolla, G.; Toppe, D.; Krause, G.; Kochlamazashvili, G.; Luetzkendorf, J.; Schedina, I. M.; Kerkhoff, Y.; Reifenstein, E.; von Kleist, M.; Herzog, H.; Albrecht, A.; Schmitz, D.; Haucke, V.; Sigrist, S. J.; Maglione, M.

2025-06-22 neuroscience
10.1101/2025.06.20.660653 bioRxiv
Show abstract

Macroautophagy/autophagy, a critical cellular degradation pathway essential for maintaining neuronal proteostasis, declines with age and has been increasingly implicated in the regulation of synaptic integrity and circuit resilience. Neuropeptide Y (NPY), the most abundantly expressed neuropeptide in the mammalian brain, has emerged as a key modulator of both autophagy and aging-related processes. In Drosophila, the NPY-family peptide short Neuropeptide F (sNPF) has been shown to causally influence aging-associated changes in synaptic architecture and function, particularly at the presynaptic active zone (AZ), via non-cell autonomous mechanisms. Extending this concept to mammals, we investigated whether NPY and autophagy interact within NPY-secreting neurons to regulate age-related AZ remodeling. Our results indicate that hypothalamic NPY/AgRP neurons may exert geroprotective effects through the release of NPY and potentially other signaling molecules, thereby influencing both metabolic homeostasis and brain-wide synaptic function. These data suggest a conserved role for autophagy in maintaining presynaptic organization and resilience during aging.

Published in Autophagy (predicted rank #3) · training set

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