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Epigenetic age acceleration links atherogenic dyslipidaemia, inflammageing and frailty with adverse cardiovascular outcomes in older adults (UFO): a lipid-metabolome and epigenetic clock analysis
2025-06-10
geriatric medicine
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BackgroundFrailty and chronic inflammatory diseases are known risk factors for adverse outcomes and have been associated with epigenetic age acceleration (EAA), a quantitative estimation of biological age based on DNA methylation. We investigated the interrelationships between EAA, atherogenic dyslipidaemia and frailty; determined the best performing epigenetic clock for EAA estimation of atherosclerotic cardiovascular disease (ASCVD) risks; and prospectively analysed the capacity of EAA to pred...
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