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Proteomic and genetic insights into ancestry-specific associations in Parkinson disease

2025-06-06 neurology Title + abstract only
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Genome-wide association studies of Parkinsons disease (PD) have identified multiple genetic variants across populations, but the biological mechanisms remain largely unknown. To investigate ancestry-specific disease pathways, we performed a series of Mendelian randomisation analyses, integrating GWAS results with ancestry-specific protein quantitative trait loci data. For Europeans, we utilised the UK Biobank plasma proteomics (UKB-PPP) dataset alongside a European PD GWAS. For East Asians, we c...

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