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Shifting Dynamics of DENV2 in Costa Rica: Emergence of the Cosmopolitan Genotype (2024)

Gonzalez Elizondo, M.; Picado Soto, D.; Cordero Laurent, E.; Duarte Martinez, F.; Alcantara, L. C. J.; Fonseca, V.; Mendez Rico, J.; Lourenco, J.; Franco, L.; Giovanetti, M.; Soto Garita, C.

2025-05-29 infectious diseases
10.1101/2025.05.28.25328475 medRxiv
Show abstract

Dengue remains a major public health challenge. In Costa Rica, we implemented the first nationwide genomic surveillance to track the emergence of the DENV2 Cosmopolitan genotype. Phylogenetic and eco-epidemiological analyses revealed early detection, climate-linked spread, and spatial heterogeneity. Findings underscore the need for integrated surveillance to guide adaptive responses to emerging arboviral threats.

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