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Antibody responses following COVID-19 vaccination and breakthrough infections in naive and convalescent individuals suggests imprinting to the ancestral strain of SARS-CoV-2

2025-05-21 infectious diseases Title + abstract only
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The binding and neutralising activity of SARS-CoV-2 antibodies are important correlates of protection of current COVID-19 vaccines. SARS-CoV-2 exposure status and COVID-19 vaccine types can influence these responses and the breadth of cross-reactivity to variants. In this longitudinal cohort study, we used SARS-CoV-2-specific multiplex Luminex(R) antibody assays and live virus neutralisation of ancestral (VIC01/2020), Delta and Omicron (BA1, BA2 and BA5) SARS-CoV-2 variants to compare antigen-sp...

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