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Lactobacillus casei Shirota intervention modulates the esophageal microbiome composition in Barrett esophagus
2025-05-13
gastroenterology
Title + abstract only
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ObjectiveEsophageal adenocarcinoma (EAC) and its precursor, Barretts esophagus (BE), are associated with a pro-inflammatory, Gram-negative-dominated esophageal microbiome. We investigated whether Lactobacillus casei Shirota (LcS) consumption could shift the microbiome towards a more Gram-positive profile in BE patients. DesignIn a single-arm intervention study, 23 BE patients used LcS twice daily for 4 weeks. Endoscopic biopsies from normal squamous epithelium (NSE) and metaplastic columnar epi...
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