Comorbidity Patterns and Associated Factors of thyroid related disorders: A community-based cross-sectional study in Chinese population

This study aims to explore the patterns and associated factors of thyroid related disease comorbidity to provide a novel insight for comorbidity prevention and management. After multi-stage stratified cluster random sampling, a total of 2272 participants were recruited, and relevant data were collected through door-to-door visits and the standardized questionnaire, anthropometric measurements and biochemical examinations. Logistic regression analysis was utilized to explore potential influences, and least absolute shrinkage and selection operator (LASSO) regression was applied to control for multicollinearity between variables. We found that there were 888 individuals with thyroid disease, yielding prevalence rates ranging from 0.35% to 17.96% for thyroid related disorders. Of these, 555 enrollees had concomitant diseases and the number of comorbidity was dominated by two conditions, with subclinical hypothyroidism and hyperlipidemia being the top ranking. Female sex acted as a protective factor for thyroid disease comorbidity, while advancing age, familial history of diabetes, large waist circumference, and fast heart rate were all substantial risk factors. The risk of comorbidity rose steeply with growing waist circumference. Appropriate measures should be taken to reduce the occurrence of comorbidity and the burden of disease.