High quality genome assemblies of African cattle breeds using PacBio HiFi sequencing
Houaga, I.; Bhati, M.; Nziku, Z.; Nguluma, A.; Mapholi, N.; Nesengani, L. T.; Ogugo, M.; Sagbo, D. C. Y.; Zorobouragui, L.; Boco, M. B. Y.; Djikeng, A.; Prendergast, J. G. D.; Gorjanc, G.; Becher, H.
Show abstract
Africa has a uniquely rich cattle diversity of [~]150 breeds comprising the Bos taurus indicus sub-species, Bos taurus taurus, and their crosses. These represent [~]23% of the global cattle population. However, high quality, representative assemblies are limited for African cattle and especially for indicine breeds. Here we built high quality de novo assemblies for five important African indigenous cattle breeds using PacBio HiFi sequencing: Lagune (Bos taurus taurus), Gudali, Iringa Red and Singida White (Bos taurus indicus), and Mpwapwa (Bos taurus taurus x Bos taurus indicus). These new assemblies are the most contiguous and complete African cattle assemblies produced so far, with genome sizes of 3.25 - 3.36Gb, contiguity N50s ranging from 83.59Mb to 97.87Mb and scaffold N50s from 100.30Mb to 113.37Mb. BUSCO genome completeness scores were also higher than 99.68%, indicative of highly contiguous assemblies. These improved and highly contiguous genome assemblies are consequently a valuable resource for future African and global livestock genomic studies.
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