Development and validation of a harmonized memory score for multicenter Alzheimer's disease and related dementia research
Sanderson-Cimino, M.; Gross, A. L.; Gaynor, L. S.; Paolillo, E. W.; Saloner, R.; Albert, M. S.; Apostolova, L. G.; Boersema, B.; Boxer, A. L.; Boeve, B. F.; Casaletto, K. B.; Hallgarth, S. R.; Diaz, V. E.; Clark, L. R.; Maillard, P.; Eloyan, A.; Tomaszewski Farias, S.; Gonzales, M. M.; Hammers, D. B.; La Joie, R.; Cobigo, Y.; Wolf, A.; Hampstead, B. M.; Mechanic-Hamilton, D.; Miller, B. L.; Rabinovici, G. D.; Ringman, J. M.; Rosen, H. J.; Ryman, S. G.; Prestopnik, J. L.; Salmon, D. P.; Smith, G. E.; DeCarli, C.; Rajan, K. B.; Jin, L.-W.; Hinman, J.; Johnson, D. K.; Harvey, D.; Fornage, M.; Kra
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INTRODUCTIONList-learning tasks are important for characterizing memory in ADRD research, but the Uniform Data Set neuropsychological battery (UDS-NB) lacks a list-learning paradigm; thus, sites administer a range of tests. We developed a harmonized memory composite that incorporates UDS memory tests and multiple list-learning tasks. METHODSItem-banking confirmatory factor analysis was applied to develop a memory composite in a diagnostically heterogenous sample (n=5943) who completed the UDS-NB and one of five list-learning tasks. Construct validity was evaluated through associations with demographics, disease severity, cognitive tasks, brain volume, and plasma phosphorylated tau (p-tau181 and p-tau217). Test-retest reliability was assessed. Analyses were replicated in a racially/ethnically diverse cohort (n=1058). RESULTSFit indices, loadings, distributions, and test-retest reliability were adequate. Expected associations with demographics and clinical measures within development and validation cohorts supported validity. DISCUSSIONThis composite enables researchers to incorporate multiple list-learning tasks with other UDS measures to create a single metric.
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