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Handling Missing Data in Participants with a Baseline but No Post-baseline Data
2025-03-26
pharmacology and therapeutics
Title + abstract only
View on medRxiv
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Clinical trial participants who are randomized to treatment and have a baseline value but no post-baseline data pose a unique challenge. These patients need to be included to preserve randomization. However, there is no information about the outcome or the intercurrent events that led to missing data. Composite and hypothetical strategies can accommodate participants with no post-baseline data. The present study investigated common methods based on hypothetical strategies in example data sets an...
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