Personalized Immune Profiling in Pediatric Transplant Recipients: Linking Atypical B Cells to Vaccine Response

2025-03-26 transplantation Title + abstract only

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Immunosuppression in solid organ transplant recipients inhibits protective immune responsiveness to pathogens and vaccines. However, specific cell states that associate with failure to generate protective immunity are not known. Here, we perform scRNAseq and CyTOF analyses of PBMC from 12 pediatric solid organ transplant recipients and 8 healthy children revealing the full spectrum of immune cell states present in these individuals, and examine the association of these cell states with the gener...

Personalized Immune Profiling in Pediatric Transplant Recipients: Linking Atypical B Cells to Vaccine Response

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