Multi-level Regulatory Roles of Lactate Metabolism Gene Network in Oral Cancer: Machine Learning Insights

2025-03-20 dentistry and oral medicine Title + abstract only

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This study explores the multi-level regulatory roles of the lactate metabolism gene network in oral cancer development using machine learning models. Machine learning analysis shows that lactate-related gene expression profiles can effectively distinguish treatment groups from controls (AUC=0.933), with SLC16A1 and KIF2C being key features. Genes like PFKP, LDHA, LDHB, LDHC, and VCAN are highlighted for their biological relevance. PFKP, involved in glycolytic metabolic regulation, is significant...