Inspecting Consistency Between US and European Vitamin D Guidelines Using Physiologically-Based Pharmacokinetics Modelling
You, T.
Show abstract
According to the US official guideline for vitamin D, serum 25-hydroxyvitamin D over 125 nmol/L is linked to potential toxicity. Using a physiologically-based pharmacokinetics model based on a randomised controlled trial in Cape Town, South Africa, we showed the 2000 IU daily dose, recommended by European Food Safety Agency as a safe dose, is expected to lead to serum concentration exceeding the 125 nmol/L threshold among some children and adolescents. This highlights inconsistency between different guidelines and the need to use modelling to bridge the gap between dose and pharmacokinetics.
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